Continental Origin for Q Haplogroup Patrilineages in Argentina and Paraguay

Haplogroup Q originated in Eurasia around 30,000 years ago. It is present Y-chromosomes from Asia and Europe at rather low frequencies. Since America undoubtedly one of the continents where this haplogroup highly represented, it has been defined as founding haplogroups. Its M3 clade early described most frequent, with pan-American representation. However, was also possible to find several other clades Numerous mutations have for Q, allowing analysis its variability assignment geographic origin. We analyzed 442 samples unrelated men Argentina Paraguay belonging Q; here we report specifically on 27 (xM3) lineages. tested 3 single-nucleotide polymorphisms (SNPs) by amplified product-length polymorphism (APLP) analysis, SNPs restriction fragment length (RFLP) 15 Sanger sequencing, 17 short tandem repeats (STRs). Our approach allowed us identify five subhaplogroups. Q-M3 Q-CTS2730/Z780 are autochthonous lineages represent frequent subhaplogroups, significant representation self-defined aboriginal populations, their status previously described. The aim work continental origin remaining Thus, STR haplotypes compared them authors rest world. Even when extensively studied America, some could post-Columbian human migration Middle East.